Stanley Lab: 1998 symposium

4th SYMPOSIUM ON

THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF SCHIZOPHRENIA AND

BIPOLAR DISORDER

NOVEMBER 5 – 7, 1998

BETHESDA, MARYLAND

AGENDA

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ABSTRACT

Thursday, November 5, 1998

8:00 Continental Breakfast and Check-In

8:30: Welcome and Introduction

Robert H. Yolken, Director of the Stanley Division of

Developmental Neurovirology, Johns Hopkins University, Baltimore,

MD

SESSION I: PRESENTATIONS FROM THE STANLEY

FOUNDATION 

8:40: Detection of

Retroviral RNA in the CSF of Individuals with Schizophrenia

Håkan Karlsson, Stanley Division of Developmental

Neurovirology, Johns Hopkins University, Baltimore, MD

9:00: In Vitro Analysis of

Cerebral Spinal Fluids From Cases of First Break Psychoses

Lorraine Jones-Brando, Stanley Division of Developmental

Neurovirology, Johns Hopkins University, Baltimore, MD

9:20: Determination of

Reverse Transcriptase (RT) Activity in Clinical and Post-Mortem

Samples From Individuals with Schizophrenia and Bipolar Disorder

Frances Yee, Stanley Division of Developmental Neurovirology,

Johns Hopkins University, Baltimore, MD

9:40: Protein Alterations

in the Postmortem Frontal Lobes of Individuals with Severe

Psychiatric Disorders

Nancy Johnston, Stanley Division of Developmental

Neurovirology, Johns Hopkins University, Baltimore, MD

10:10: Simultaneous

Analysis of Expression Levels of Many Genes in Post-Mortem Brain

Tissue From Individuals With Schizophrenia and Bipolar Disease

Kia Faridi, Stanley Division of Developmental Neurovirology,

Johns Hopkins University, Baltimore, MD

10:30: Quinolinic Acid and

Psychiatric Diseases

Linda Bobo, National Institute of Mental Health, Washington

DC

10:50: Update on the

Stanley Foundation Schizophrenia Treatment Network

Michael B. Knable, Stanley Foundation, Bethesda, MD

11:10: The Stanley Foundation

Brain Bank: A Progress Report

Maree J. Webster, Stanley Foundation Research Programs,

Bethesda, MD

11:30: Membrane Fatty Acid

Metabolism and Schizophrenia

Wayne S. Fenton, Stanley Treatment Program at Chestnut Lodge,

Rockville, MD

SESSION II: VIROLOGY OF BRAIN DISORDERS

1:20: Studies on

MS-Related Sequences Identified by Amplicon-Based RDA From

Affected Members of Monozygotic Twin Pairs Discordant for

Schizophrenia

Shiva M. Singh, University of Western Ontario, London,

Ontario, Canada

1:40: Oligoclonal

Expansion of T Cells In the Brain of Children with AIDS

Emilia L. Oleszak, Fels Institute, Temple University,

Philadelphia, PA

2:00: Isolation of

Non-Host Nucleic Acids From Viliuisk Encephalomyelitis

Irina Alexeeva, Baltimore Research & Education

Foundation, Baltimore, MD

2:20: Comparative

Immunovirological Investigations of HHV-6, HHV-7, and HHV-8 in

Multiple Schlerosis (MS), Other Neurological Disorders (OND), and

Healthy Donors (HD)

Gregory V. Williams, Advanced Biotechnologies Inc., Columbia,

MD

2:40: Selective Targeting

of Habenular, Thalemic Midline and Monaminergic Neurons by

Neurotropic Influenza A Virus

Krister Kristensson, Karolinska Institute, Stockholm, Sweden

3:00 Reversible

Encephalopathy Following Exposure to Estuarine Waters Containing

Pfeisteria-Like Organisms

Christopher Bever, University of Maryland School of Medicine,

Baltimore, MD

3:20: Prenatal Human

Influenza Viral Infection in Mice Decreases the Expression of

Reelen in the Neonatal Cortex and Hippocampus

S.H. Fatemi, University of Minnesota Medical School,

Minneapolis, MN

3:40: Neural Biopsies From

Patients with Schizophrenia: Testing the Neurodevelopmental

Hypothesis In Vitro

John McGrath, Queensland Centre for Schizophrenia Research,

Wolston Park Hospital, Wacol, Australia

4:00: Regulation of Herpes

Simplex Virus Latency in Neurons in Culture

Lewis I. Pizer, University of Colorado Health Sciences,

Denver, CO

4:20: Molecular Analysis

of Schizophrenia and Bipolar Disorder by cDNA Expression Assay

Alex Chenchik, Clontech Laboratories Inc., Palo Alto, CA

SESSION III: POSTER SYMPOSIUM

Plasma

Levels of Leptin During Treatment With Antipsychotic Drugs

Thomas Pollmächer, Max Planck Institute of Psychiatry,

Munich, Germany

Plasma

Levels of Cytokines and Soluble Cytokine Receptors In the Course

of Treatment With Antidepressants

Dunja Hinze-Selch, Max Planck Institute of Psychiatry,

Munich, Germany

Replicated

Loci of the Human pMCH Genes: Antisense Expression and Potential

for Homologous Recombination

Christine Miller, University of Colorado,

Denver, CO

The

Immunological Alterations in Major Depression Are Not Caused by

Antidepressant Medication

Marion Peters, University of Lübeck, Germany

Duration

of Untreated Psychosis Is Associated With a Poor Treatment

Response In Schizophrenia

Silke Bachmann, University of Heidelberg,

Heidelberg, Germany

Magnetic

Resonance Imaging Correlates of Duration of Untreated Psychosis

in Schizophrenia

Silke Bachmann, University of Heidelberg, Heidelberg, Germany

Vß1+

T Cells Are Clonally Expanded in the Spinal Cord of TMEV-Infected

Mice

Emilia L. Oleszak, Temple University School of Medicine,

Philadelphia, PA

Angiocentric

CD3+ T-Cell Infiltrates in HIV-1-Associated CNS Disease in

Children

Emilia L. Oleszak, Temple University School of Medicine,

Philadelphia, PA

Tumor-Infiltrating

Lymphocytes in Patients WIth Glioblastoma Multiforme Contain

Oligoclonal Populations of T-Cells

Chris D. Platsoucas, Temple University

School of Medicine, Philadelphia, PA

Indication

for Ganciclovir Therapy in a Schizophrenic Patient

W. John Martin, Center for Complex Infectious Diseases,

Rosemead, CA

Testing

for Proteins with Polyglutamine Expansions in the Stanley

Foundation Brain Collection

Alan H. Sharp, Dept. of Psychiatry and

Behavioral Sciences, Johns Hopkins University, Baltimore, MD

Glutamic

Acid Decarboxylase (GAD) Autoantibody Positivity in Schizophrenia

Eileen Kemether, Mount Sinai School of

Medicine, New York, NY

Reduced

Prevalence of Psychoses in Genetic Isolate?

Joseph W. Eaton, UPMC, Pittsburgh, PA

Qigong,

A Potential Alternative Medicine for Neuropsychiatric Disorders

Guoqiang Xing, Uniformed Services University of the Health

Sciences, Bethesda, MD

Discovering

the Genes Affected by Schizophrenia Using DNA Micro-Array

Yang Qiu, Lawrence Berkeley National Lab, Berkeley, CA

Abnormal

Expression of Neural Cell Adhesion Molecule in Schizophrenia

Marquis P. Vawter, NIDA Addiction Research Center, Baltimore,

MD

SINE-R.C2

(A Homo Sapiens Specific Retroposon) is Homologous to cDNA from

Post-Mortem Brain in Schizophrenia and to Two Loci n the

Xq21.3/Yp Block Linked to Handedness and Psychosis

Heui-Soo Kim, Department of Psychiatry,

Warneford Hospital, University of Oxford, United Kingdom

FRIDAY, NOVEMBER 6, 1998

8:00: Continental Breakfast

SESSION I: PERINATAL FACTORS AND

PSYCHIATRIC DISEASES

A. What We Can Learn from the

Prospective Perinatal Cohort (CPP) Study

8:30: Introduction

E. Fuller Torrey, Executive Director, Stanley Foundation,

Bethesda, MD

8:40: Infection,

Inflammation, Cytokines and Cerbral Palsy

Karin Nelson, National Institute of Neurological and

Communicative Disorders and Stroke, Bethesda, MD

9:10: Viruses, Fetal

Hypoxia and Subsequent Schizophrenia: A Direct Test of Infectious

Agents Using Prenatal Sera

Stephen L. Buka, Harvard School of Public Health, Boston, MA

9:40: Prospective Studies

of Neurodevelopmental Influences in Schizophrenia

Tyrone D. Cannon, Department of Psychology, University of

Pennsylvania, Philadelphia, PA

10:10: A New Approach to Design

and Data Analysis for CPP-Based Studies that Make Use of Sera,

and Experience with Recent Laboratory Analysis of CPP Sera

Matthew P. Longnecker, National Institute of Environmental

Health, Research Triangle Park, NC

B. Perinatal Factors and Psychiatric

Diseases

10:50: Deep White Matter

Abnormalities on MRI Are Linked to Winter Births in Bipolar

Patients

Peter Brian Moore, Newcastle University, United Kingdom

11:10: Season of Birth and

Schizophrenia: A Systematic Review and Meta-Analysis of Data From

the Southern Hemisphere

John McGrath, Queensland Centre for Schizophrenia Research,

Wolston Park Hospital, Wacol, Australia

11:30: Fetal Mild

Ventriculomegaly Detected In Utero by Ultrasound: A Risk

Factor for Schizophrenia?

John Gilmore, University of North Carolina, Chapel Hill, NC

PLENARY SPEAKER

1:30: Virus-Immune

Interactions In the Pathogenesis of Theiler’s Virus Demyelinating

Disease

Raymond P. Roos, University of Chicago Pritzker School of

Medicine, Chicago, IL

SESSION II: IMMUNOLOGY OF BRAIN DISEASES

2:30: Immunomodulatory

Effects of Psychotropic Drugs

Dunja Hinze-Selch, Max Planck Institute of Psychiatry,

Munich, Germany

3:00: Effects of

Granulocyte Colony-Stimulating Factor on Sleep in Human

Andreas Schuld, Max Planck Institute of Psychiatry, Munich,

Germany

3:20: Interferon Gamma in

Schizophrenia–An Overview

Matthias Rothermundt, University of Lübeck, Germany

3:40: Immune Alterations in

Postpartum Depression and Maternity Blues

Michael Maes, Clinical Research Center for Mental Health,

Belgium

4:00: Altered Alterations

of B Cell Activation in CSF of Schizophrenic Patients

Norbert Müeller, University of Munich, Germany

4:20: Viral and Immune

Hypotheses In Schizophrenia: An Epigenetic Perspective

Art Petronis, Clarke Institute of Psychiatry, Toronto,

Ontario, Canada

4:40: What Does Disease

Discordance Mean in Monozygotic Twins?

Cassandra Smith, Boston University, Boston, MA

BREAK

6:00: Poster Viewing (Wine, Cheese and

Light food)

SESSION III: SYMPOSIUM ON BORNA INFECTIONS

7:00: Developmental Brain

Injury Associated with Abnormal Social behaviors in Neonatally

BDV-Infected Rats: A Model for Autism

Kathryn M. Carbone, Food and Drug Administration, Rockville,

MD

7:20: Does Borna Disease Virus

Cause Neuropsychiatric Disorders?

Karl Bechter, Dept. Psychiatry II, University of Ulm, Germany

7:50: Borna Disease Virus and

the Brain

Juan Carlos de la Torre, The Scripps Research Institute,

LaJolle, CA

8:20 POSTER PRESENTATIONS

Prevalance

of Borna Disease Virus (BDV) RNA in the Peripheral Leukocytes of

French Subjects: Preliminary Results

Marie-Edith Lafron, Virology Laboratory,

Bordeaux2-Victor Segalen University, France

Failure

to Detect Borna Disease Virus p24 and p40 mRNA in 60 Autopsy

Brain Samples of the Stanley Foundation Brain Collection

Kazuhiko Ikeda, Tokyo Institute of

Pyschiatry, Tokyo, Japan

Electrochemiluminescence

Immunoassay for Measurement of Anti-Borna Disease Virus p40/p24

Antibody in Animal and Human Sera

K. Yamaguchi, Kumamto University School of

Medicine, Japan

High

Sensitivity Detection of Neurotropic Viruses in Postmortem Brain

Tissue by In Situ PCR and In Situ RT-PCR

Regina W. Einsiedel, Ruprecht-Karls-Univesitat, Heidelberg,

Germany

Cerebrospinal Fluid Filtration As

Experimental Treatment In a Case of Borna Disease

Virus-Encephalitis-Related Schizophrenia

Karl Bechter, Dept. Psychiatry II University of Ulm, Germany

SATURDAY, NOVEMBER 7, 1998

8:00: Continental Breakfast

SESSION I: ISSUES IN PSYCHIATRIC DISEASES

9:00: Update on The Epidemiology of

Psychiatric Diseases-Should You Put Out the Cat at Night

E. Fuller Torrey, Stanley Foundation, Bethesda, MD

9:30: Differential

Display Idnetifies Novel Targets for the Actions of Mood

Stabilizing Agents Lithium (LI) and Valproate (VPA)

Husseini K. Manji, Molecular Pathophysiology Program, WUS School

of Medicine

PLENARY SPEAKER

10:00: Retroviral Elements

Associated with Superantigens and Neurotoxins: Learnings From Our

Research in Multiple Sclerosis and Possible Avenue of Research in

Neurological Diseases

Herve Perron, bioMérieux, S.A., Lyon, France

11:00: SUMMARY AND CONCLUSIONS

Robert H. Yolken, M.D., Director, Stanley Division of

Developmental Neurovirology, Johns Hopkins University School of

Medicine, Baltimore, MD

Last revised on 05 July 2000.

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