2003 STANLEY MEETINGS
NOVEMBER 6-8, 2003
BETHESDA MARRIOTT SUITES HOTEL
BETHESDA, MARYLAND
NOVEMBER 6 – ENDOGENOUS RETROVIRUSES
NOVEMBER 7 – GENOMICS AND PROTEOMICS
NOVEMBER 8 – MOLECULAR BIOLOGY OF BIPOLAR DISORDER
AGENDA
NOVEMBER 6 – ENDOGENOUS
RETROVIRUSES (Click on title to read “Abstract”)
8:30:
Introduction to the Programs and Resources of the Stanley
Medical Research Institute
Robert Yolken, Michael Knable, Maree Webster
8:45:
Why Look for Infectious Agents in Schizophrenia and Bipolar Disorder?
E. Fuller Torrey
9:00:
Human Endogenous Retrovirus W in
Schizophrenia
Håkan Karlsson
9:30:
The Human Endogenous Retrovirus W Gag Protein
Sarven Sabunciyan
10:00:
Studies of HERV-W and Neutral Amino Acid Transporters (ASCT 1
and 2) in the Brains of Patients with Schizophrenia, Bipolar Disorder and
Depression
Serge Weis
10:45:
of MSRV Envelope targeting Brain Macrophages/Microgliocytes: A
Common Pathogenic Pathway for Multiple Sclerosis and Schizophrenia, with Common
Immunotherapeutic Outcomes?
Hervé Perron
11:15:
Retroviral
Sequences of the Human Genome. Characterisation and RNA Expression
Jonas Blomberg
11:45:
HERV-K Polymorphisms in Human Populations
John Coffin
13:30
Endogenous Retroviruses and Resistance to Exogenous
Retrovirus Infection
Jonathan Stoye
14:00
Contrasting
Evolutionary Histories of Different HERV Families
Javier Costas
14:30
Recent Evolution
of HERV-K
Jack Lenz
15:15:
Impact of
Retroelements on Human Gene Regulation
Patrik Medstrand
15:45:
Contributions of Endogenous LTRs to Transcriptional
Regulation of
Dixie Mager
16:15:
HERVd: A Comprehensive Database of Human
Endogenous Retroviruses
Vaclav Paces
16:45:
NP9 Protein of the Human Endogenous Retrovirus K interacts
with LNX
(Ligand of Numb Protein)
N. Mueller-Lantzsch
POSTER SYMPOSIUM
19:30
of Retroviral Activity in Human Brain and Tissues
Oliver Frank
19:40:
Viral Microarray
Studies: Retroviruses
Concha Goldberg
19:50:
Studies of the Novel
Endogenous Murine Leukemia Provirus HEMV
Christopher Tipper
20:00:
The Expression of the
HERV-K Envelope Proteins Alters Gene Expression in Raji Cells
Sarven Sabunciyan, Lorraine Brando
20:10:
Endogenous Retrovirus HERV-W Proteins in Human
Brains: Evidence for
Pathophysiological Modulation of Gag and
Env Expression in Demyelinating Disease
Hervé Perron
20:20:
MSRV (Multiple Sclerosis Associated Retrovirus) Displays
Pro-Inflammatory
Properties on Antigen Presenting Cells
Patrice Marche
20:30:
Measuring mRNA Quality in Postmortem Human
Brain Tissue
Suad Diglisic, Christine Miller
Additional Posters:
A Method to Detect Conserved Transposable Element
Insertions in Orthologous
Patrik Medstrand
HERV-K (HML-2) Insertions Distinguishing Human Genome
from Non-Human
Yuri Lebedev
NOVEMBER 7 – GENOMICS AND PROTEOMICS
9:00: Measuring mRNA
Quality in Postmortem Human Brain Tissue
Christine
Miller
9:30:
Mitochondrial Dysfunction in Schizophrenia: Evidence for Oxidative Stress and
Abnormal Growth Factor Support
Sabine Bahn
10:00:
A Proteomics Approach: Towards the
Understanding of Schizophrenia and Bipolar Disorder
Janie
Swatton
10:45: Aberrant
Gene Expression in Hippocampal Dentate Granule and CA3 Neurons in
Multiple Groups of Schizophrenic Patients
C. Anthony Altar
11:15: Analysis of
Gene Expression, RNA Edition, and Mitochondrial DNA Deletion,
In The Stanley Foundation Brain Bank Samples
Tadafumi Kato
13:15: Recent
Findings of a Proteomic Analysis of Anterior Cingulate Cortex in Major
Psychiatric
Disorders and Future Directions In
This Area
David Cotter, Michael Dunn
13:45: Abnormal
Carbohydrate Metabolism in Mood and Psychotic Disorders: Linking Pathway
Flux to Proteomics in Postmortem Brain
William Regenold
14:15: Viral
Detection Arrays: Application to Schizophrenia
Concha Goldberg
14:45: Association
of Key SNP Genotypes with Gene Expression Patterns in the
Orbitofrontal Cortex of Normal
Controls
Carlo Colantuoni
15:30:
Differential Gene Expression in Cortical Regions
Marquis Vawter
16:00:
Retroelements in Major Psychosis
Arturas Petronis
16:30: DNA
Methylation of HTR2A, DRD2 & RELN Genes Promoters in Schizophrenia
Hamid Abdolmaleky
POSTER SYMPOSIUM
19:00:
Studies of Metabolic Dysfunctions in
Schizophrenia
Stephen Huffaker
19:10:
Interpretation of Affymetrix Gene Expression Results With Respect to Patient
Margaret Ryan
19:20:
Proteomics Investigations on Blood Cells from Schizophrenia Patients
Prabakaran Sudhakaran
19:30:
Quantitative PCR Validating Affymetrix
Data-The Transcript Problem!
Michael Mimmack
19:40:
Protein Expression Abnormalities in
Bipolar Disorder
Martina Wengenroth
19:50:
Metabolic Abnormalities in Schizophrenia
Dmetri Tkachev
20:00: Use of
Laser Capture Microdissection and Microarray Technology to Identify Drug
and Disease-Associated transcriptional Changes in
Hippocampal Neurons
Vinod Charles, Jeffrey Brockman
20:10: Abnormal
Carbohydrate Metabolism in Mood and Psychotic Disorders: Linking Pathway
Flux to Proteomics in Postmortem
Brain
William Regenold
20:20: DNA
Microarray Studies of Prenatal Virally-Exposed Mouse Brains
D. Hossein Fatemi
20:30:
DNA Microarray Analysis of the Prefrontal Cortex in
Bipolar Disorder
K. Iwamoto
20:40:
Analyzing Expression Profiles of Valproate Regulated Genes and Genes Involved in
Bipolar
Jun-Feng Wang
Additional Poster:
The Use of Flow Cytometric Based Multiplex Assays in
the Analysis of Cytokines and
Growth Factors From CSF and Serum in
Schizophrenia
Rachel Craddock
NOVEMBER 8 – THE MOLECULAR AND CELLULAR
UNDERPINNINGS OF BIPOLAR
DISORDER
9:05: Cellular
Regulation of BABA Cells in Bipolar Disorder
Francine Benes
9:30:
GABAergic Molecular Pathology in Bipolar
Disease
John Davis
10:10 Mitochondrial
Dysfunction in Bipolar Disorder
Tadafumi Kato
10:35:
Calcium Dysregulation in Bipolar Disorder
Jerry Warsh
11:00: Glycogen
Synthase Kinase-3b
Haploinsufficiency Mimics the Behavioral and Molecular Effects
Peter Klein
12:25:
Prolyloligopeptidase, Lithium and Inositol Phosphates
Adrian Harwood
13:00:
Genomic Studies Identify Neurotrophic Cascades in Bipolar
Disorder
Husseini Manji
13:25:
Effect and Therapeutic Potential of Mood Stabilizers
De-Maw Chuang
13:50:
ER Stress Proteins as Therapeutic Targets in Bipolar
Disorder
Trevor Young
14:15:
Morphometric Evidence for Lithium’s Neuroprotective
Effects
Gwendolyn Wood
15:00:
Increases Glial Proliferation: A Therapeutic Role
Lei Zhang
15:25:
Genomics Studies of Bipolar Disorder
Sabine Bahn
15:50:
Gene Expression Discovery in Post-Mortem Human Brain:
Bipolar and Major Depressive
Marquis Vawter
16:15:
Cell-Based Assays for Drug Discovery in Bipolar Disorder
Pascal Laeng
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Michael Knable, Robert Yolken, E. Fuller Torrey Stanley Medical Research Inst. and Johns Hopkins University |
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Javier Costas and Robert Yolken Universidade de Santiago de Composela, Spain and Johns Hopkins University |
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HERVE PERRON AND SERGE WEIS BioMerieux, France and Stanley Medical Research Institute |
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Patrice Marche Laboratoire d’Immunochimie, INSERM, France |
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Walter Lech Tufts University School of Medicine, |
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Frances Yee and Robert Yolken Former Stanley Faculty Member Johns Hopkins University |
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Raphael Viscidi and E. Fuller Torrey Johns Hopkins University – Stanley Division Stanley Research Medical Institute |
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Dixie Mager Terry Fox Laboratory, Canada |
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Håkan Karlsson and Sarven Sabunciyan
Past and Current Fellows in the Stanley Division of the Johns Hopkins University
Dr. Karlsson now at Karolinska Institute in Sweden |
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Dr. Robert Yolken enjoys lunch with some of the participants |
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Ann Cusic, Administrative Manager for the Stanley Division of the Johns Hopkins University |
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Christine Miller, Research Associate Stanley Division of the Johns Hopkins University |
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Christopher Tipper and Walter Lech, Tufts University School of Medicine Sarven Sabunciyan, Fellow, Stanley Division of the Johns Hopkins University |
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Jonas Blomberg, Uppsala University, Sweden Lorraine Brando, Research Associate, Stanley Division of the Johns Hopkins University |
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Jeffrey Brockman, Pascal Laeng and C. Anthony Altar Psychiatric Genome, Inc.,Gaithersburg, Maryland |
