POSTER

Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute,

We performed the

oligonucleotides microarray analysis in 60 postmortem prefrontal cortices of the

Stanley Foundation Brain Collection.  By comparing the gene expression profiles,

we explored the uniqueness of bipolar disorder at the molecular level.  Most of

the altered gene expressions in each disease were not shared by one another. We

found a tendency of down-regulation of the genes encoding receptor, channels or

transporters, and up-regulation of the genes encoding stress response proteins

or molecular chaperons in bipolar disorder.  Altered expressions in bipolar

disorder shared by other mental disorders mainly consisted of up-regulation of

the genes encoding proteins for transcription or translation. In addition, we

found the altered expression of LIM and HSPF1 both in the brains

and lymphoblastoid cells in bipolar disorder.  These genes would be novel