LOW MATERNAL VITAMIN D AS A RISK FACTOR FOR SCHIZOPHRENIA: A PILOT STUDY USING BANKED SERA
J McGrath, D Eyles, B Mowry, R Yolken, S Buka
OBJECTIVE: Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia
METHOD: Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamir D3 in mothers of individuals with schizophrenia or schizoaffected disorders versus mothers of unaffected controls. For each case, we selected two control matched on race, gender and date of birth of the offspring.
RESULT: There was no significant difference in third trimester maternal vitamin D in the entire sample (Cases = 26, controls = 51). Within the subgroup of black individuals (n=21), there was a trend level differences in the predicted direction.
CONCLUSIONS: Maternal vitamin D does not operate as a continuous graded risk factor for schizophrenia, however, the results in the black subgroups raise the possibility that below a certain critical threshold, low levels of maternal vitamin D may be associated with an increased risk of schizophrenia.