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HSV1 EXPOSURE AFFECTS PREFRONTAL CORTICAL STRUCTURE IN SCHIZOPHREIA PATIENTS

Molecular Psychiatry (2007) 12, 1

KMR Prasad1, BH Shirts1, RH Yolken2, MS Keshavan1,3, and VL Nimgaonkar1

1Departmetn of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 2Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD USA and 3Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA

Differences in grey matter among herpes simplex virus 1 [HSV1]-seropositive and HSV1-seronegative schizophrenia patients and healthy subjects: the left panel shows grey matter differences within schizophrenia and healthy subject groups by HSV1 serological status. Significant reductions in grey matter in the prefrontal region can be seen in schizophrenia patient with serological evidence of exposure to HSV1 compared to those with no evidence of exposure but not within healthy subjects. The right panel shows significant changes in grey matter in the prefrontal region in HSV1-seropositive patients compared to seropositive health subjects. Such differences were not observed between.

 

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