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ELECTROCHEMILUMINESCENCE IMMUNOASSAY FOR MEASUREMENT OF ANTI-BORNA DISEASE VIRUS p40/p24 ANTIBODY IN ANIMAL AND HUMAN SERA K. Yamaguchi*, T. Sawada, S. Yamane, K. Ikeda, R. Igata-Yi, Y. Horii, RW Waltrip II, KM Carbone. Kumamoto University School of Medicine, Eisai Tsukuba Research Laboratory, Tokyo Inst. Psych, Veteran Int. Med, Japan, University of Maryland Psychiatric Research Center, Division …

Electrochemiluminescence Immunoassay for Measurement of Anti-Borna Disease Virus p40/p24 Antibody in Animal and Human Sera Read More »

TOXOPLASMA INFECTION AND BEHAVIOURAL CHANGES–ANIMAL MODEL Toxoplasma infection is prevalent amongst rodents, but, as in humans, acute postnatal infection seems to be an infrequent cause of morbidity or mortality.  However, long standing Toxoplasma infection has recently been associated with significant alterations in rodent behaviour.  In mice, long standing Toxoplasma infection is associated with increased movement, …

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  FUNCTIONAL GENOMICS STUDIES OF BIPOLAR DISORDER   Sabine Bahn and Colleagues   Babraham Institute, Cambridge, UK Stanley Laboratories, Johns Hopkins, Baltimore, MD, USA and Bethesda, MD, USA       Results of microarray studies on human post-mortem tissue have suggested abnormalities in lipid- and myelin-related genes in the prefrontal cortex of schizophrenia1-3.  Recently we …

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Viral and Cellular Determinants of HIV Dementia S Gartner, Y Liu, E Hunter and JC McArthur   Current models for HIV dementia implicate not only HIV infections and replication, but also immune activation within the brain.  The temporal relationship between these, however, and the relative contributions of each to the disease process, remain points of …

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 GENOMIC STUDIES IDENTIFY NEUROTROPHIC CASCDES IN BIPOLAR DISORDER   Rulun Zhou, Patricia Damschroder-Williams, Peixiong Yuan, Guang Chen and Husseini K. Manji Laboratory of Molecular Pathophysiology, NIMH, NIH, Bethesda, MD 20892, USA     Mood stabilizing agents require chronic administration for therapeutic efficacy, a temporal profile which suggests alterations at the genomic level. A series of …

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The Stanley Laboratory of the Johns Hopkins University The Stanley Laboratory was founded in 1996 to promote research into the role of infectious agents in the etiology and pathogenesis of schizophrenia and bipolar disorder.  The Stanley Laboratory is fully supported by the Stanley Medical Research Institute (www.stanleyresearch.org).  Some of the scientific background of the Laboratory’s …

The Stanley Laboratory of the Johns Hopkins University Read More »

Simultaneous Analysis of Expression Levels of Many Genes in Post-Mortem Brain Tissue from Individuals with Schizophrenia and Bipolar Disease K. Faridi*, K. Hyder, A. Chenchik, N.L. Johnston, R.H.Yolken, and the Stanley Neuropathology Consortium. The Stanley Division of Developmental Neurovirology Johns Hopkins University School of Medicine, 600 N. Wolfe St./Blalock 1111 Baltimore, MD 21287-4933, USA The …

Simultaneous Analysis of Expression Levels of Many Genes

and Bipolar Disease Read More »

    LOW MATERNAL VITAMIN D AS A RISK FACTOR FOR SCHIZOPHRENIA: A PILOT STUDY USING BANKED SERA J McGrath, D Eyles, B Mowry, R Yolken, S Buka Schizophrenia Research 2003 Sept. 1;63(1-2):73-8     ABSTRACT OBJECTIVE:  Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:  Based …

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PREVALENCE OF BORNA DISEASE VIRUS (BDV) RNA IN THE PERIPHERAL LEUKOCYTES OF FRENCH SUBJECTS: PRELIMINARY RESULTS Marc Auriacombe, Emmanuelle Cotto, Didier Neau, Isabelle Faure, Muriel Denayrolles, Véronique Dubois, Jean-Marie Ragnaud, Jean-Luc Pellegrin, Jean Tignol, Hervé Fleury, Marie-Edith Lafon* Virology Laboratory, Bordeaux 2-Victor Segalen University, France BDV RNA was detected in German, northern American and Japanese …

Prevalance of Borna Disease Virus (BDV) RNA in the

Peripheral Leukocytes of French Subjects: Preliminary Results Read More »