7th SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISORDER FOCUS ON GENOMICS, PROTEOMICS, AND CLINICAL TRIALS AGENDA Genomics and Proteomics INTRODUCTION TO THE STANLEY BRAIN COLLECTION E. Fuller Torrey and Maree Webster, Stanley Medical Research Institute CHARACTERISTICS OF RNA THAT AFFECT cDNA GENERATION AND ARRAY HYBRIDIZATION Christine L. Miller and Robert H. …
VIRUS-IMMUNE INTERACTIONS IN THE PATHOGENESIS OF THEILERS VIRUS DEMYELINATING DISEASE Raymond P. Roos, M.D. The University of Chicago, Department of Neurology, Chicago, IL. Viruses use varied strategies in order to avoid the hosts immune response. This is especially true in the case of persistent infections, when viruses must both initiate and maintain infection despite immune …
Virus-Immune Interactions In the Pathogenesis of Theiler’sVirus Demyelinating Disease Read More »
QUALITATIVE ASSESSMENT OF RETROVIRAL ACTIVITY IN HUMAN BRAIN AND TISSUES Wolfgang Seifarth, Udo Zeilfelder, Bigit Spiess, Rüdiger Hehlmann and Christine Leib-Mösch III. Medizinische Klinik, Universitätsklinikum Mannheim We have developed a fast and reliable high throughput method for the investigation of retroviral activity in biological samples. The qualitative assay allows detection as well as identification …
QUALITATIVE ASSESSMENT OF RETROVIRAL ACTIVITY IN HUMAN BRAIN AND TISSUES Read More »
OLIGODENDROCYTE DYSFUNCTION IN SCHIZOPHRENIA AND BIPOLAR DISORDER Dmitri Takchev, Michael L. Mimmack, Margaret M. Ryan, Matt Wayland, Tom Freeman, Peter B. Jones, Michael Starkey, Maree J. Webster, Robert H. Yolken, Sabine Bahn Lancet 362:798-805, 2003 SUMMARY Background: Results of array studies have suggested abnormalities in expression of lipid and myelin-related genes in schizophrenia. Here, we …
OLIGODENDROCYTE DYSFUNCTION IN SCHIZOPHRENIA AND BIPOLAR DISORDER Read More »
POSTER QUANTITATIVE PCR VALIDATING AFFYMETRIX DATA – THE TRANSCRIPT PROBLEM! Michael L. Mimmack1,2, Steve Huffaker1,2, Margaret Ryan1,2, and Sabine Bahn1,2 1Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK; 2Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK Affymetrix Genechip technology offers an opportunity to …
PROTEIN ALTERATIONS IN THE POSTMORTEM FRONTAL LOBES OF INDIVIDUALS WITH SEVERE PSYCHIATRIC DISORDERS N. Johnston *, L. Anderson, N. Anderson, a. Shore, R. Yolken and E.F. Torrey Johns Hopkins University, Stanley Division of Developmental Neurovirology, Baltimore MD Two-dimensional gel electrophoresis is an objective means to compare the levels of individual proteins in different samples. We …
Protein Alterations in the Postmortem Frontal Lobes of
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Gene Expression Gene Expression Discovery in Post-Mortem Human Brain: Bipolar and Major Depressive Disorders M.P. Vawter1, H. Tomita1, S. Evans2, P. Choudary3, J. Li4, B. Bolstad5, J. Lopez2, T. Speed5, R.M. Myers4, S.J. Watson2, H. Akil2, E.G. Jones3, W.E. Bunney1 1 Department of Psychiatry University of California, Irvine CA 2 MHRI, University of …
Gene Expression Gene Expression Discovery in Post Read More »
POSTER MITOCHONDRIAL DYSFUNCTION IN SCHIZOPHRENIA: OXIDATIVE STRESSING S. Huffamer1,2, M. Ryan1,2, and S. Bahn1,2 1Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK; 2Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 1QQ, UK The onset and etiology of schizophrenia has been implicated with a wide range of …
REPLICATED LOCI OF THE HUMAN pMCH GENES: ANTISENSE EXPRESSION AND POTENTIAL FOR HOMOLOGOUS RECOMBINATION Christine L. Miller*, Margit Burmeiser and Robert C. Thompson University of Michigan, IL The pro-melanin concentrating hormone (pMCH) gene has a feature common to many peptidergic genes, i.e. the production of a peptide precursor molecule that is then processed into more …
Replicated Loci of the Human pMCH Genes: Antisense
Expression and Potential for Homologous Recombination Read More »
ALTERED LEVELS OF REELIN AND ITS ISOFORMS IN SCHIZOPHRENIA AND MOOD DISORDERS SH Fatemi, University of Minnesota Reelin is a secreted extracellular matrix protein ~410kDa mol wt that is reduced in brains of patients with schizophrenia, autism, bipolar disorder and major depression. Recent reports also indicate its near absence in sera of some patients with …
ALTERED LEVELS OF REELIN AND ITS ISOFORMS IN SCHIZOPHRENIA AND MOOD
DISORDERS Read More »
