Schizophrenia Res 2000 Nov 30;46(1):17-23
The Antecedents of Psychoses: A Case-Control Study
of Selected Risk Factors
Fuller Torrey E, Rawlings R, Yolken RH
Winter birth, urban birth and/or childhood
residence, and perinatal complications have each been identified as
environmental risk factors for the later development of schizophrenia,
schizoaffective disorder, and bipolar disorder. A preliminary case-control
study also identified cat exposure in childhood as a possible risk factor.
To assess selected environmental events, including childhood exposure to pets,
as possible risk factors for these diseases, a case-control telephone survey was
carried out by the University of Maryland Survey Research Center for 264 mothers
of cases and 528 mothers of matched controls. The cases were randomly
selected mothers who were members of the National Alliance for the Mentally Ill,
and whose children had been diagnosed with schizophrenia, schizoaffective
disorder, or bipolar disorder. The controls were mothers randomly selected
from the same telephone exchanges. For five of the 19 major variables, there
were statistically significant differences between case and controls: fever
during pregnancy, complications during delivery, city or suburban residence at
birth, cat ownership between birth and age 13, and breast-feeding. In a
multivariate logistic regression including these five variables, each variable
made a significant contribution. The finding of perinatal complications,
urban/suburban residence at birth, and cat ownership in childhood as risk
factors for the later development of psychoses confirmed previous studies.
Previous research on breast-feeding as a risk factor has yielded contradictory
results. Additional research is needed to ascertain how such environmental
risk factors interact with genetic risk factors. Understanding these could
lead to better treatments and possible prevention strategies.