HERVd: A
COMPREHENSIVE DATABASE OF HUMAN ENDOGENOUS RETROVIRUES
Jan
Paces, Adam Pavlicek and Vaclav Paces
Institute of Molecular Genetics, Academy of Sciences, CZ-16637 Prague, Czech
Republic
The human endogenous retroviruses database (HERVd) has
been developed at the Institute of Molecular Genetics, Academy of Sciences of
the Czech Republic, and is accessible via World Wide Web at
http://herv.img.cas.cz. HERVd provides complex
information on the retroviral elements (HERVs) found in the human genome. It is
being continuously updated so that the present version contains virtually all
elements including both elements with the classical retroviral structure (LTR-gag-pol(pro)-env-LTR)
and also nonautonomous elements that diverged considerably from the typical
retroviral genome. It can be used for searches of individual HERV families,
identification of HERV fragments, comparison of HERVs and their structures and
identification of retroviral integration sites. Both text and graphical outputs
of individual elements are available. The total number of different HERV
families in the database is now over 150. The database can be searched by
nucleotide sequences for DNA and protein similarities using FASTA and BLAT.
Finally, the database is integrated with the human annotation and each element
is linked to the UCSC genome browser.