STATISTICAL ANALYSES OF GENOMIC AND PROTEOMIC MEASUREMENTS IN HUMANPOSTMORTEM BRAIN TISSUE

confounding variables unless consideration is given to matching tissue samples

prior to investigation.  Of particular interest to researchers working with

postmortem brain tissue are the affects of tissue pH, post-mortem interval,

refrigeration interval, and days in storage.  These and other variables may

affect the level of RNA or protein measured using genomic or proteomic

methodologies.  As these types of measurements are relatively new, and the

data produced are different from previous types of data, there are many

statistical questions to address when analyzing the data.  We will discuss

several different approaches to these analyses and address the limitations and