SIMILARITIES AND DIFFERENCES IN NEURAL CIRCUITRY CHANGES IN THE LIMBIC LOBE OF
SCHIZOPHRENIC AND BIPOLAR SUBJECTS.
Benes, F.M.,Burke, R.,
Walsh, J., Berretta, S., Masilovich, D., Minns, M.
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA;
Program in Neuroscience and Department of Psychiatry, Harvard Medical School,
A compilation of results from postmortem
studies of the anterior cingulate cortex over the past 12 years have revealed
both similarities and differences when schizophrenic and bipolar groups have
been compared. For markers of the GABA system, there is a great deal of overlap
in the findings for the two patient groups when compared to normal controls. On
the other hand, results obtained from analyses of the glutamate system and
apoptosis have suggested that intracellular signaling and metabolic pathways may
behave differently in schizophrenic and bipolar subjects. Taken together, these
results are consistent with a “two factor model” of psychotic disorders in which
environmental factors common to schizophrenia and bipolar disorder may affect
the GABA system, while specific susceptibility gene(s) for the respective
diagnostic groups may be reflected in the differences observed for the
regulation of apoptotic cascades. Overall, these findings raise the possibility
that the development of novel pharmacologic treatments that are uniquely
effective in the treatment schizophrenic versus bipolar disorder may find a
basis in the transcriptional regulation of complex intracellular signaling that
mediate the response to oxidative stress. Supported by MH00423, MH42261,
MH62822 and MH60450.