3rd SYMPOSIUM ON THE NEUROVIROLOGY AND
NEUROIMMUNOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISORDER
OCTOBER
23 25, 1997
BETHESDA, MARYLAND
AGENDA
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Thursday,
October 23, 1997
8:00: Continental Breakfast and
Check-In
8:30: Welcome and Introduction
Robert H. Yolken,
Director, Stanley Neurovirology Laboratory, Johns Hopkins
University
SESSION I:
Presentations from the Stanley Laboratory, Johns Hopkins
University School of Medicine
8:40: Description of the
Stanley Neuropathology Program
E. Fuller Torrey,
Scientific Director, Stanley Foundation
Protein Species and Levels in Human Frontal Cortices: A
Preliminary Study of Protein Variations Between Mentally Ill and
Unaffected Individuals
Nancy L. Johnston, Ph.D.
9:20 Viral and
Virus-Associated RNA Transcripts Are Differentially Expressed in
the Brains of Individuals with Schizophrenia and Bipolar Disorder
Frances Yee, Ph.D.
Expression of Brain Tissue From Individuals With Schizophrenia
and Bipolar Disorder
Yeping Sun, Ph.D.
10:00 B R E A K
10:20 Epidemiologic Correlates
of Interleukin-2 Receptor in Postmortem CSF and Sera of
Individuals with Schizophrenia and Bipolar Disorder
Linda D. Bobo, Ph.D.
10:40 Spinophilin: Alterations
In A Postsynaptic Marker in Schizophrenia
Indra De , Ph.D.
11:00 Screening For Viral
Nucleic Acid Sequences in CSF and Brain Tissue Obtained Post
Mortem From Patients With Schizophrenia and Bipolar Disorder
Hakan Karlsson, Ph.D.
11:20 PCR Methods for
Differential Display of Retroviral LTR Sequences Using tRNA
Binding Sites and DNA Binding Motifs of Transcription Factors as
Primers
Raphael P. Viscidi,M.D.
11:40 L U N C H B R E A K
(Coupon in file folder)
SESSION
II: Pathophysiological
Mechanisms of Viral Infection and Neuropsychiatric Diseases
1:30 Protein Kinase C
Signaling Cascade and Bipolar Disorder: Therapeutic Implications
Husseini K. Manji,
Molecular Pathophysiology Program, WSU School of Medicine
1:50 Herpes Simplex Virus
Latent Infection of the Central Nervous System
Richard B. Tenser, Penn
State University College of Medicine
2:10 Identification of a
Herpes Simplex Virus Genetic Element Involved Neurovirulence
Jeng-Yang Ling,
University of Arkansas For Medical Sciences
2:30 Systemic Infection Alters
Neurotrophic Factor mRNA
John H. Gilmore,
Department of Psychiatry, University of North Carolina School of Medicine
TMEV-Infected SLJ Mice
Emilia L. Oleszak, Fels
Institute for Cancer Research and Molecular Biology and
Department of Biochemistry and Neurology, Temple University
School of Medicine
3:10 B R E A K
3:30 Cathecholaminergic
Transmission During Newcastle Disease Virus Infection in Chicks
Valluru Lokantha,
Department of Zoology, Sri Unkateswara University
SESSION
III: METHODS FOR THE MEASUREMENT OF NUCLEIC ACIDS AND PROTEINS
Expression by Mood Stabilizing Agents
Husseini K. Manji,
Molecular pathophysiology Program, WSU School of Medicine
4:10 Gene Expression Discovery
System (GEDSSM): A Fluorescent Differential Display
Methodology for Rapid Expression Survey and Analysis of Nearly
All Genes
Babak Azad, SRA
Technologies Inc.
4:30 Genomic Differential
Display: An Alternative to Positional Cloning
Cassandra Smith, Boston
University, Center for Advanced Biotechnology and Departments of
Biomedical Engineering, Biology and Pharmacology
4:50 Analysis of Brain
Proteins by 2-Dimensional Electrophoresis
N. Leigh Anderson, Large
Scale Biology
D
I N N E R B R E A K
SESSION IV:
POSTERS
7:00 Poster Viewing (Wine and Cheese)
7:30: Poster Symposium
of Differentially Expressed Messages From the Postmortem Brains
of Schizophrenic and Bipolar Individuals
Nancy L. Johnston,
Stanley Neurovirology Laboratory, Johns Hopkins University
of Epidemiologic and Pathologic Variables with IL-2 Cytokine,
IL-2 Receptor and Quinolinic Acid Levels of Individuals with
Schizophrenia, Bipolar Disorder, Unipolar Depression or Normal
Controls
Jose D. Paltan-Ortiz,
NIMH Neuroscience Center, Stanley Foundation Research Program
Interleukin-2 Receptor Levels in Families of Patients With
Schizophrenia
Fiona Gaughran,
Department of Psychiatry, United Medical and Dental School of St
Guys and Thomas
Oxide Synthase (iNOS) and Nitrotyrosine Are Found in Acute But
Not In Chronic Multiple Sclerosis Lesions
Emilia L. Oleszak, Fels
Institute for Cancer Research and Molecular Biology and
Department of Biochemistry and Neurology, Temple University
School of Medicine
Herpes Simplex Virus Type 1 Encephalitis Affects Adults
Sensorimotor Gating Function in Rats
Jorgen A. Engel,
Department of Pharmacology, Goteborg University
Lorraine Brando, Stanley
Neurovirology Laboratory, Johns Hopkins University School of
Medicine
Dysfunction in Hippocampal Neurons Induced by Mumps Virus
Infection
Krister Kristensson,
Stanley Foundation European Research Center, Dept. Neuroscience,
Karolinska Institute
Pathology in Young Suicide Victims
Z. Srebo, Department of
Biology, Collegium Medicum, Jagiellonian University
and Leadership: A Contrasting Model for the Deficit Symptoms: A
Role for Sex Hormonal Dysgenesis?
A.G. Alias, Chester
Mental Health Center
Affective Disorders and Infantile Autism: Ultrastructual
Alterations in Platelets
Segundo Mesa, Psychiatric
Hospital of Havana
Syndrome: Results of Interview and Psychologic Testing
John L. Black, Mayo
Foundation, Mayo Clinic
FRIDAY,
OCTOBER 24, 1997
8:00 Continental
Breakfast
8:30 PLENARY SPEAKER
Epidemiology Can Tell About Multiple Sclerosis
John F.
Kurtzke, Neuroepidemiology Section, Neurology Service, VAMC,
Washington DC
SESSION I:
EPIDEMIOLOGY AND PATHOGENESIS OF HUMAN NEUROPSYCHIATRIC DISEASES
Affective Disorders: A Tale of Two Viruses
Alan S. Brown, New York
Sate Psychiatric Institute
First Admissions of Schizophrenia and Affective Disorder In An
Irish National Sample
Mary Clarke, Stanley
Research Unit, Cluain Mhuire Family Centre, St. John of God Adult
Psychiatric Services
10:10 B R E A K
10:30 Characterization of
Retroviral Sequences Isolated From Monozygotic Twins Discordant
for Schizophrenia Using Representational Difference Analysis
(RDA)
Shiva M. Singh, Molecular
Genetics Unit, Department of Zoology, The University of Western
Ontario
10:50 Epidemic Stealth Virus
Infection
W. John Martin, Center
for Complex Infectious Diseases
11:10 Possible Antibody
Cross-Reactivity Between Retroviral and Brain Antigens
Darrenn J. Hart,
Department of Psychiatry and Neurology, Tulane University
11:30
Schizophrenia: Alternative Responses to Brain Injury, Infection
or Maldevelopment: Are Ever Larger Sample Sizes and Metanalyses
Muddying the Waters?
Janice R. Stevens, Oregon
Health Sciences University
12:00 L U N C H (Coupon in file
folder)
SESSION II:
AUTOIMMUNITY AND PSYCHIATRIC DISEASES
1:30 Correlation of IL-2
Receptor Levels in CSF of Individuals with Schizophrenia Bipolar
Disorder, Unipolar Depression or Normal Controls With
Immunohistochemical Localization in the Brain
Maree Webster, Stanley
Foundation Research Program, NIMH Neuroscience Center
1:50 Identical T-Cell Receptor
Transcripts Are Clonally Expanded in CNS of THEV-Infected Mice
With Early Acute & Late Chronic Demyelinating Disease
Emelia L. Oleszak, Fels
Institute for Cancer Research and Molecular Biology and
Department of Biochemistry and Neurology, Temple University
School of Medicine
SESSION
III: EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF BORNA VIRUS
INFECTION (Chaired by Dr. Kathryn Carbone)
2:10 Plenary Speaker
Virus Infection: Pathogenesis, Disease and Diagnosis in
Experimentally and Naturally Infected Species
Lothar
Stitz, Institute for Vaccines, Federal Research Center for Virus
Diseases of Animals, Tjbingen, Germany
2:40 Detection and Sequence
Analysis of Borna Disease Virus P24 RNA From Peripheral Blood
Mononuclear Cells of Patients With Major Depression and
Schizophrenia
Yasuhide Iwata Department
of Microbiology and Neuropsychiatry, Fukushima Medical College,
Japan
3:00 B R E A K
3:20 Borna Disease Virus
Genomes in Autopsy Brain Samples From Control and Schizophrenia
in Japan
Kazuhiko Ikeda,
Department of Ultrastructure and Histochemistry, Tokyo Institute
of Psychiatry
3:40 Nuclear Targeting
Activity Associated With the Amino-Terminus of Borna Disease
Virus Nucleoprotein
Masahiko Kishi, Institute
of Immunological Science, Hokkaido University, Japan
the Protein from the ORFx1 of the Borna Disease Virus
Tahir H. Malik,
Department of Biosciences, Salem-Teikyo University
Response in the Central Nervous System Following Infection with
Borna Disease Virus
Carolyn G. Hatalski,
Laboratory for Neurovirology, University of California-Irvine
Central Nervous System of Rats Infected with Borna Disease Virus
Mady Hornig, Laboratory
for Neurovirology, University of California-Irvine
Virus in Psychiatric Patient
Koji Fukuda, Department
of Microbiology and Neuropsychiatry, Fukushima Medical College,
Japan
5:20 The Quagmire of BDV
Diagnostic Tests
Kathryn M. Carbone,
Laboratory of Pediatric and Respiratory Viral Diseases, FDA
D I N N E R B R E A K
7:00 Wine and Cheese Reception
Open
Microphone Session
SATURDAY,
OCTOBER 25, 1997
8:00 Continental Breakfast
9:00 Plenary Speaker
C.N.S. Infections and Adult Onset Psychosis
Peter
Jones, University of Nottingham
10:00 What We Know About the
Epidemiology of Schizophrenia and Bipolar Disorder
E. Fuller Torrey,
Scientific Director, Stanley Foundation
11:00 Summary and Conclusions
Robert H. Yolken,
Director, Stanley Neurovirology Laboratory, Johns Hopkins
University School of Medicine
The
4th Symposium on the Neurovirology and
Neuroimmunology of Schizophrenia and Bipolar Disorder
will be held in Bethesda, Maryland, on November 5-7,
1998. Tentative plenary speakers are Dr. Robin Weiss,
Professor of Viral Oncology, The Institute of Cancer
Research, London and Dr. Raymond Roos, Chairman of the
Department of Neurology, University of Chicago.