Stanley Lab: Agenda 1996

2nd Symposium on

The Neurovirology and Neuroimmunology of Schizophrenia and

Bipolar Disorder

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Thursday, November 14, 1996

8:00-9:00: Check in and Continental Breakfast

SESSION I:

THE STANLEY NEUROVIROLOGY LABORATORY OF THE JOHNS

HOPKINS UNIVERSITY

9:00: Robert H. Yolken:

Overview of the Stanley Laboratory Program-Do We Really Think

that Infections Can Cause Human Psychiatric Diseases.

9:20: Frances Yee:

Viral

and Virus-Related RNA Transcripts Are Differentially Expressed in

the Brains of Individuals with Schizophrenia.

9:40: Linda Bobo:

Correlation of Schizophrenia and Bipolar Disorder with Cytokine

and Cytokine Receptors in Ventricular Fluids and Postmortem Brain Tissue.

10:00: Nancy Johnston:

Measurement of RNA from 89 Postmortem Human Brains; A

Multivariate Statistical Analysis of Pre- and Post Mortem Effects

on the Yields of GAPdH As Measured by RT-PCR.

10:20: Indra De:

Detection

of Viral Particles in Glial Cells Inoculated with Brain Tissue

from Individuals with Schizophrenia and Bipolar Disease.

10:40: COFFEE BREAK

11:00: Yeping Sun:

Serial

Analysis of Gene Expression of Human Brain Tissue.

11:20: Raphael Viscidi:

Genomic Differential Display Enriched for Retroviral LTR

Sequences.

11:40-1:30: LUNCH

SESSION II: OTHER

NEUROLOGICAL AND INFECTIOUS DISEASES-WHAT CAN BE APPLIED TO THE

UNDERSTANDING OF SCHIZOPHRENIA AND BIPOLAR DISEASE

1:30: Sangram S. Sisodia, Johns Hopkins University,

Department of Pathology and Neurosciences, Baltimore, MD:

Molecular Biology of Alzheimer’s Disease.

2:00: Christopher Ross, Johns Hopkins University,

Department of Neurobiology, Baltimore, MD: Genetics of Huntington’s Disease: Lessons for

Psychiatry.

2:30: Krister S. Kristensson, Karolinska Institutet,

Department of Neurosciences, Stockholm, Sweden: Trypanosoma Brucei Dysregulates the Mammalian

Circadian Clock.

3:00: Lorraine Jones-Brando, Johns Hopkins University,

The Stanley Neurovirology Laboratory, Baltimore, MD:

Cytomegalovirus and Post-Transplant

Arteriosclerosis.

3:20: BREAK

3:35: Shizuku Sei, National Institutes of Health, NCI,

Bethesda, MD: Virological Aspects of

Neuropathogenesis of HIV-1 Disease.

3:55: Larisa Cervenakova, National Institutes of

Health, Laboratory of the Central Nervous System Studies,

Bethesda, MD: DNA Polymorphism and

Susceptibility to Environmentally Acquired Creutzfeldt-Jakob

Disease.

4:15: Steven Jacobson, National Institutes of Health,

Neuroimmunology Branch, Bethesda, MD:

Association of HHV-6 and Multiple Sclerosis.

4:35: Dharam V. Ablashi, Georgetown University Medical

School, Washington DC: Higher

Frequency of Human Herpesvirus-6 (HHV-6) Antibody in Cerebral

Spinal Fluids and Sera from Multiple Sclerosis Patients.

DINNER BREAK

SESSION III: POSTERS

7:00-8:00: Poster Viewing

(Wine and Cheese provided)

Arlene Collins, SUNY,

Department of Microbiology, Buffalo, NY: Susceptibility of Human Macrophages to

Coronavirus OC43.

Paromita Deb, The

University of Western Ontario, Department of Zoology, London,

Ontario: Investigation of

Insertional Mutagenesis of “Retroid” Elements in the

Human Genome with Reference to Schizophrenia.

John H. Gilmore, University

of North Carolina School of Medicine, Department of Psychiatry,

Chapel Hill, NC: Neonatal Infection

Increases Neurotrophic Factor mRNA.

Frederick W. Hickling,

Psychotherapy Associates, Connoley House, Kingston, Jamaica:

The Incidence and Prevalence of Bipolar

Affective Disorder in Jamaica.

Nancy Johnston, Johns

Hopkins University, Stanley Neurovirology Laboratory, Baltimore,

MD: Comparison of cDNA Libraries

From the Brains of Normal and Schizophrenic Individuals Show Than

an Unusually High Number of Novel Sequences are Present in the

Brain of the Schizophrenic Individual.

Timothy A. Klempan, The

University of Western Ontario, Department of Zoology, London,

Ontario: The Application and

Adaptation of Representational Difference Analysis in the

Evaluation of Retroviral Hypothesis for Schizophrenia.

Mark H. Rapaport,

University of California San Diego, Department of Psychiatry, La

Jolla, CA: A Pilot Study of Cytokine

and Soluble Interleukin-2 Receptor Levels in Symptomatic Bipolar

Patients.

Chettemgere Venkateshan,

LCNSS, NINDS, NIH, Bethesda, MD:

Effect of HTLV-1 Virus, IFN-y and Quin Precursors on Quin

Response in Cultured Human Monocytes and Macrophages.

8:00-9:30: Poster

Discussions and Answer

 

Friday, November 15, 1996

SESSION I: INFECTIONS AND

HUMAN PSYCHIATRIC DISEASES

PLENARY SPEAKER

9:00: Erling Norrby,

Karolinska Institute, Microbiology and Tumor Biology Center,

Stockholm, Sweden: Measles Virus

Invasion Through Limbic Structures in Mice with Disrupted Gene

for the Transporter Associated with Antigen Presentation.

10:00: Alan S. Brown, NYS Psychiatric Institute/Columbia

University, New York, NY: Psychosis

After Prenatal Exposure to Rubella.

10:20: Mady Hornig-Rohan, University of Pennsylvania,

University Science Center, Depression Research Unit,

Philadelphia, PA: Rates of Flu-Like

Illness in Patients with Affective Disorders.

10:40: BREAK

11:00: W. John Martin,

Center for Complex Infectious Diseases, Rosemead, CA:

Instability of SCMV-Derived Stealth Viral

Genome.

11:20: Susan Swedo, National Institutes of Mental

Health, Bethesda, MD: PANDAS: Is

There a New “Species” of Pediatric Neuropsychiatric

Disorders?

11:40: Brad D. Pearce, Emory University School of

Medicine, Department of Psychiatry, Atlanta, GA: The Immune Response in the Disruption of

Hippocampal GABA Circuits Following Neonatal Infection with

Lymphocytic Choriomeningitis Virus (LCMV).

12:00-1:30: LUNCH

SESSION II: IMMUNOLOGY AND

PATHOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISEASE

1:30: Mark H. Rapaport, University of California San

Diego, Department of Psychiatry, LaJolla, CA: Evidence of Differences in Immune Function in

Older & Younger Schizophrenic Patients: Is This Age or A

Function of Severity of Illness.

1:50: Pinkhas Sirota, Abarbanel Mental Health Center,

Bat-Yam Felsenstein Medical Institute, Bat-Yam, Israel:

Antibodies to Neural Tissue Proteins in

Schizophrenic Patients.

2:10: van Kammen, Daniel P., Department of Veterans

Affairs, Medical Center, Pittsburgh, PA: The Role of Immune Measures in Psychosis and

Stress Sensitivity in Schizophrenia.

2:30: Barbara B. Mittleman, NIMH, Unit on

Neuroimmunology, Behavioral Pediatrics Section, Child Psychiatry

Branch, Bethesda, MD: The Role of

Cytokines in Untreated and Treated Childhood Onset Schizophrenia.

2:50: BREAK 

3:10: Steve Zalcman, Concordia University, Department

of Psychiatry, Montreal, Canada:

Interleukin-6 Sensitizes Rats to the

Locomotor-Activating Effects

of Amphetamine.

3:30: Guoqiang Xing, National Institutes of Mental

Health, Bethesda, MD: PPARõ And Its

Potential Involvement in Schizophrenia.

3:50: Cassandra L. Smith, Boston University,

Departments of Biomedical Engineering, Biology and Pharmacology,

Boston, MA: Detection and

Quantitation of Genomic Differences in Microsatellites of

Monozygotic Twins.

4:10: N.L. Anderson, Large Scale Biology Corporation,

Rockville, MD: Characterization of

Disease Processes and Pharmaceutical Mechanisms Through

Quantitative High-Throughput 2-D Electophoresis.

4:30: Jhy-Jhu Lin, Life Technologies, Inc (GIBCO/BRL),

Gaithersburg, MD: A New PCR-Based

DNA Fingerprinting Method: AFLP.

4:50: Janice R. Stevens, Oregon Health Sciences

University, Department of Psychiatry, Portland, OR:

Do the Anatomy and Course of Schizophrenia

Assist In the Search for Etiology?

DINNER BREAK

SESSION III: EPIDEMIOLOGY

AND PATHOPHYSIOLOGY OF BORNA DISEASE

7:00: Kathryn Carbone, FDA, Laboratory of Pediatric

& Respiratory Viral Diseases, Bethesda, MD: Borna Disease Virus in Psychiatric Disease.

7:30: Juan C. de la Torre, The Scripps Research

Institute, La Jolla, CA: Borna

Disease Virus in Humans.

7:50: Royce W. Waltrip II, Maryland Psychiatric

Research Center, Baltimore, MD:

Borna Disease Virus Serology in a First Episode Schizophrenia

Cohort.

8:10: Masahiko Kishi, Hokkaido University Institute of

Immunological Science, Section of Bacterial Infection, Sapporo,

Japan: Prevalence of Borna Disease

Virus RNA in Peripheral Blood Mononuclear Cells From Patients

with Affective Disorders.

8:30: D. Craig Hooper, Thomas Jefferson University,

Center for Neurovirology, Department of Microbiology and

Immunology, Philadelphia, PA: Is

Active Borna Disease Virus Infection Really a Contributor to

Human Psychiatric Disorders?

8:50: Joanne M. Pyper, Johns Hopkins University School

of Medicine, Division of Comparative Medicine, Baltimore, MD:

Neural Development Patterns in Rats Infected

with Borna Disease Virus As Neonates.

 

Saturday, November 16, 1996

PLENARY SPEAKER

9:00: Stanley B. Prusiner, University of California San

Francisco, Department of Neurology, San Francisco, CA:

The Molecular Biology and Genetics of Prion

Diseases: A Journey from Heresy to Orthodoxy.

10:00: E. Fuller Torrey, Guest Researcher, NIMH

Neurosciences Center, Washington DC:

Where Have We Been and Where are We Going: Risk Factors and

Future Directions.

10:15: Robert H. Yolken, Director, The Stanley

Neurovirology Laboratory of the Johns Hopkins University,

Baltimore, MD: Closing Comments

 

Last revised on 05 June 2000.

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