Stanley Lab: 1995 Agenda

1st

SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF

SCHIZOPHRENIA AND BIPOLAR DISORDER

AGENDA (Click on

title for abstract)

FRIDAY,

NOVEMBER 3, 1995

8:00:

Continental Breakfast/Sign In

8:30: Welcome and Introduction. Robert H. Yolken, M.D.,

Director, Stanley Neurovirology Laboratory of the Johns Hopkins

University School of Medicine.

8:40: Viruses and Psychiatric Disease–Does the

Connection Make Sense? Robert H. Yolken.

SESSION

I: PRESENTATIONS FROM THE STANLEY NEUROVIROLOGY LABORATORY OF THE

JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

9:00: Viral Transcription Factor RNAs Are Differentially

Expressed in the Brains of Individuals With Schizophrenia.

Frances Yee, Ph.D.,

Stanley Fellow, Johns Hopkins University.

9:15: Metabolites of Clozapine Inhibit the Replication

of Neurotropic Viruses.

Lorraine V. Brando, Ph.D., The Stanley

Neurovirology Laboratory, Johns Hopkins University.

9:30: A Comparison of Cytokine Transcripts from Selected

Brain Areas Between Individuals with Schizophrenia and Controls.

Linda Bobo, Ph.D., The

Stanley Neurovirology Laboratory, Johns Hopkins University.

9:45: Brain Libraries Indicate Differential RNA

Expression in Schizophrenia and Bipolar Disease.

Nancy Johnston, Ph.D.,

Stanley Fellow, Johns Hopkins University.

10:00: Assessment of Genomic Difference Between Liver and

Brain of a Schizophrenic Patient. Naderah

Jafari, Ph.D., Stanley Fellow,

Johns Hopkins University.

10:15:

BREAK

10:30: Infection of Neural Cells with Brains from

Individuals with Schizophrenia.

Indra Dé, Ph.D., Stanley Fellow, Johns

Hopkins University.

10:45: Analysis of Genomic DNA from Patients with

Schizophrenia. Yeping Sun, Ph.D., Stanley Fellow, Johns Hopkins

University.

KEYNOTE

SPEAKER

11:00: Effects of Viruses on Limbic System Neurons and

Neurotransmittters: Implications for Schizophrenia and Bipolar

Disorder.

Krister Kristensson, M.D., Ph.D., Department of Neurosciences,

Karolinska institute, Stockholm, Sweden.

12:00:

LUNCH

SESSION

II: ETIOLOGIC AGENTS OF PSYCHIATRIC DISEASE–INFECTION AND

IMMUNITY

1:30: Retroviral Antibodies in Schizophrenics: Possible

Immunomodulation by Psychotropic Drugs.

Darrenn J. Hart, Tulane

University School of Medicine.

1:45: Maternal Influenza, Obstetric Complications and

Schizophrenia. Padraig Wright, Pfizer Central Research, UK.

2:00: Mapping of a Herpes Simplex Virus Genetic Element

Involved in Neurovirulence and Neuroinvasiveness. Jeng-Yang Ling, Baylor

College of Medicine.

2:15: IgM Antibodies to Eight Common Neurotropic Viruses

in the Serum Samples of Schizophrenic Patients and Controls from

South India.

V. Ravi, NIMHNS, India.

2:30: HSV1 in Brain: An Environmental Risk Factor in

Alzheimer’s Disease. Ruth F. Itzhaki, University of Manchester, UK.

2:45: Retinoic Acid Response Element DNA Motifs in

Viruses May Affect Retinoid Cascade in Schizophrenia.

Ann B. Goodman, Nathan

S. Kline Institute.

3:00: Relationship of Anti-Streptococcal and

Anti-Neuronal Antibodies in Patients with Tourette’s Syndrome and

Obsessive Compulsive Disorder.

Daniel M. Tucker, Yale University School

of Medicine.

3:15:

BREAK

3:30: State Dependent Immune Disturbances in

Schizophrenia. Daniel P. van Kammen, Department of Veterans

Affairs Medical Center, Pittsburgh, PA.

3:45: Prediction of Relapse from Changes in Cytokine and

Antibody Production in Schizophrenia. Rohan Ganguli, Western

Psychiatric Institute and Clinic.

4:00: Evaluation of 6 Measures of Central Nervous System

Immune Activation in CSF or Patients with Schizophrenia.

George R. Heninger, Yale

University School of Medicine.

4:15: Acute Phase Proteins in Affective

Illness. Mady Hornig-Rohan,

Depression Research Unit, University of Pennsylvania.

4:30: Enumeration of CD34+ Hematopoietic Stem Cells in

Schizophrenic Individuals Receiving Clozapine.

Henrietta Kulago,

National Institute of Mental Health.

4:45: The Immune System Alterations in Psychiatric

Disorders: The Causes of Appearance and the Mechanisms of Development.

Galina Kolyaskina, National Mental Health Research Center,

Russia.

DINNER

BREAK

FRIDAY

EVENING

SESSION

III: BIOLOGY AND EPIDEMIOLOGY OF BORNA DISEASE VIRUS

7:00: Introduction. Robert H. Yolken, M.D.

7:05: Overview of the Biology of Borna Virus As Applied

to Psychiatric Diseases. Kathryn Carbone, M.D., The Johns Hopkins

University, Division of Infectious Diseases, Department of

Medicine.

7:15: Experimental Borna Disease as a Model for

Immune-mediated Abnormalities in the Brain.

Lothar Stitz, Institut

für Virologie, Germany.

7:30: Severe Neurological Symptoms in Mice Infected with

Borna Disease Virus. Peter Staeheli, University of Freiburg, Germany.

7:45: Quantitative Correlation of Viral Induced Damage

to the Hippocampus and Spatial Learning and Memory Deficits. Kathryn M. Carbone, The

Johns Hopkins University.

8:00: Prefrontal Cortex Dysfunction in Rats Infected

with Borna Disease Virus.

W. Ian Lipkin, University of California, Irvine.

8:15: Detection, Isolation and Molecular

Characterization of Human BDV. Daniel

Gonzalez-Dunia, The Scripps

Research Institute.

8:30: Schizophrenia and Borna Disease – Clinical

Relationships in a Monozygotic Twin Study Cohort.

Royce W. Waltrip III,

Maryland Psychiatric Research Center.

8:45:

OPEN MICROPHONE PRESENTATIONS AND DISCUSSIONS

SATURDAY,

NOVEMBER 4, 1995

SESSION

I: INFECTIOUS AGENTS AND PSYCHIATRIC DISEASE — POTENTIAL

MECHANISMS

KEYNOTE

SPEAKER

9:00: Virus Infection of Neurons, Disordered CNS

Function and Resultant Neuropsychiatric Disease. Michael B. A. Oldstone,

M.D., The Scripps Research Institute.

9:45: The Immunopathogenesis of Virus-Induced

Myocarditis. Noel

R. Rose, M.D., Ph.D., The Johns Hopkins University.

10:15: Viral Models for Persistent Neurological Infection.

Diane Griffin, M.D.,

Ph.D, The Johns Hopkins University.

10:45:

BREAK

11:00:

Geographic Correlation of Schizophrenia and

Ixodes Tick-Borna Viruses. James S. Brown, M.D., U.S. Military Academy.

11:15: Simultaneous Analysis of Multiple DNA Suspects

From Twins Discordant for Schizophrenia.

Cassandra L. Smith,

Boston University.

11:30: Calcium Dysregulation in Major Mood

Disorders. Martha M. Coetzee,

Uniformed Services University of the Health Sciences.

11:45: Viral Research in Schizophrenia: Phenomenological

Considerations. William T. Carpenter, University of Maryland

School of Medicine.

12:00

LUNCH/POSTER PRESENTATIONS

Possible Suppression of Herpes Simplex Virus

Infections with Lithium Carbonate.

Jay D. Amsterdam, Greg Maislin,

University of Pennsylvania Medical Center.

Viral Etiology and Seasonality of Schizophrenic

Births in Barbados. Ram Rao Malesu, K. McKenzie, R. Murray, Institute

of Psychiatric, Genetics Sections, London.

A 7-Year Prospective Study of Long-Term Lithium

Effect on Affective and Labial Herpes Recurrences in Bipolar Patients.

Janusz K. Rybakowski and Jay D. Amsterdam, Department of Adult

Psychiatry, University of Medical Sciences, Poland and University

of Pennsylvania Medical Center.

Seroepidemiological Studies of Prenatal Viral

Infection and Adult Schizophrenia. Alan S. Brown, New York State Psychiatric

Institute.

SESSION

II: ANIMAL MODELS OF PSYCHIATRIC DISEASES

1:00: A New Foamy Retrovirus From An Orang-Utan With

Encephalopathy. Myra O. McClure, St. Mary’s Hospital Medical

School, U.K.

1:15: Virus-Induced Pathology in the Developing

Hippocampus May Involve Disruption of Inhibitory Circuits.

Brad D. Pearce, Emory

University School of Medicine.

1:30: Altered Brain FYN Kinase in a Murine

AIDS. Yoshitatsu Sei, NIDDK,

NIH.

1:45: Surrogate Markers’ for Encephalopathy in the

SIV-Infected Rhesus Monkey.

Lee E. Eiden, National Institute of Mental

Health.

2:00: Attempts to Passage a Transmissible Growth Agent

From CSF of Schizophrenic Patients to Neonatal Mice.

Janice R. Stevens,

Oregon Health Sciences University.

2:15: Localization of Viral Message in Brains of Cats

Exposed Postnatally to Bovine Viral Diarrhea Virus.

Susan E. Bachus,

National Institute of Mental Health.

2:30: Decreased Levels of A Lipid in the Brain Frontal

Lobe in Patients With Schizophrenia. Subrato Chatterjee, The Johns Hopkins

University School of Medicine.

2:45:

OPEN MICROPHONE PRESENTATIONS AND DISCUSSION

3:15: Meeting Summary and Conclusions. E. Fuller Torrey, M.D.,

National Institute of Mental Health.

Last revised on 05 June 2000.

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