1st
SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF
SCHIZOPHRENIA AND BIPOLAR DISORDER
AGENDA (Click on
title for abstract)
FRIDAY,
NOVEMBER 3, 1995
8:00:
Continental Breakfast/Sign In
8:30: Welcome and Introduction. Robert H. Yolken, M.D.,
Director, Stanley Neurovirology Laboratory of the Johns Hopkins
University School of Medicine.
8:40: Viruses and Psychiatric Disease–Does the
Connection Make Sense? Robert H. Yolken.
SESSION
I: PRESENTATIONS FROM THE STANLEY NEUROVIROLOGY LABORATORY OF THE
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
9:00: Viral Transcription Factor RNAs Are Differentially
Expressed in the Brains of Individuals With Schizophrenia.
Frances Yee, Ph.D.,
Stanley Fellow, Johns Hopkins University.
9:15: Metabolites of Clozapine Inhibit the Replication
of Neurotropic Viruses.
Lorraine V. Brando, Ph.D., The Stanley
Neurovirology Laboratory, Johns Hopkins University.
9:30: A Comparison of Cytokine Transcripts from Selected
Brain Areas Between Individuals with Schizophrenia and Controls.
Linda Bobo, Ph.D., The
Stanley Neurovirology Laboratory, Johns Hopkins University.
9:45: Brain Libraries Indicate Differential RNA
Expression in Schizophrenia and Bipolar Disease.
Nancy Johnston, Ph.D.,
Stanley Fellow, Johns Hopkins University.
10:00: Assessment of Genomic Difference Between Liver and
Brain of a Schizophrenic Patient. Naderah
Jafari, Ph.D., Stanley Fellow,
Johns Hopkins University.
10:15:
BREAK
10:30: Infection of Neural Cells with Brains from
Individuals with Schizophrenia.
Indra Dé, Ph.D., Stanley Fellow, Johns
Hopkins University.
10:45: Analysis of Genomic DNA from Patients with
Schizophrenia. Yeping Sun, Ph.D., Stanley Fellow, Johns Hopkins
University.
KEYNOTE
SPEAKER
11:00: Effects of Viruses on Limbic System Neurons and
Neurotransmittters: Implications for Schizophrenia and Bipolar
Disorder.
Krister Kristensson, M.D., Ph.D., Department of Neurosciences,
Karolinska institute, Stockholm, Sweden.
12:00:
LUNCH
SESSION
II: ETIOLOGIC AGENTS OF PSYCHIATRIC DISEASE–INFECTION AND
IMMUNITY
1:30: Retroviral Antibodies in Schizophrenics: Possible
Immunomodulation by Psychotropic Drugs.
Darrenn J. Hart, Tulane
University School of Medicine.
1:45: Maternal Influenza, Obstetric Complications and
Schizophrenia. Padraig Wright, Pfizer Central Research, UK.
2:00: Mapping of a Herpes Simplex Virus Genetic Element
Involved in Neurovirulence and Neuroinvasiveness. Jeng-Yang Ling, Baylor
College of Medicine.
2:15: IgM Antibodies to Eight Common Neurotropic Viruses
in the Serum Samples of Schizophrenic Patients and Controls from
South India.
V. Ravi, NIMHNS, India.
2:30: HSV1 in Brain: An Environmental Risk Factor in
Alzheimer’s Disease. Ruth F. Itzhaki, University of Manchester, UK.
2:45: Retinoic Acid Response Element DNA Motifs in
Viruses May Affect Retinoid Cascade in Schizophrenia.
Ann B. Goodman, Nathan
S. Kline Institute.
3:00: Relationship of Anti-Streptococcal and
Anti-Neuronal Antibodies in Patients with Tourette’s Syndrome and
Obsessive Compulsive Disorder.
Daniel M. Tucker, Yale University School
of Medicine.
3:15:
BREAK
3:30: State Dependent Immune Disturbances in
Schizophrenia. Daniel P. van Kammen, Department of Veterans
Affairs Medical Center, Pittsburgh, PA.
3:45: Prediction of Relapse from Changes in Cytokine and
Antibody Production in Schizophrenia. Rohan Ganguli, Western
Psychiatric Institute and Clinic.
4:00: Evaluation of 6 Measures of Central Nervous System
Immune Activation in CSF or Patients with Schizophrenia.
George R. Heninger, Yale
University School of Medicine.
4:15: Acute Phase Proteins in Affective
Illness. Mady Hornig-Rohan,
Depression Research Unit, University of Pennsylvania.
4:30: Enumeration of CD34+ Hematopoietic Stem Cells in
Schizophrenic Individuals Receiving Clozapine.
Henrietta Kulago,
National Institute of Mental Health.
4:45: The Immune System Alterations in Psychiatric
Disorders: The Causes of Appearance and the Mechanisms of Development.
Galina Kolyaskina, National Mental Health Research Center,
Russia.
DINNER
BREAK
FRIDAY
EVENING
SESSION
III: BIOLOGY AND EPIDEMIOLOGY OF BORNA DISEASE VIRUS
7:00: Introduction. Robert H. Yolken, M.D.
7:05: Overview of the Biology of Borna Virus As Applied
to Psychiatric Diseases. Kathryn Carbone, M.D., The Johns Hopkins
University, Division of Infectious Diseases, Department of
Medicine.
7:15: Experimental Borna Disease as a Model for
Immune-mediated Abnormalities in the Brain.
Lothar Stitz, Institut
für Virologie, Germany.
7:30: Severe Neurological Symptoms in Mice Infected with
Borna Disease Virus. Peter Staeheli, University of Freiburg, Germany.
7:45: Quantitative Correlation of Viral Induced Damage
to the Hippocampus and Spatial Learning and Memory Deficits. Kathryn M. Carbone, The
Johns Hopkins University.
8:00: Prefrontal Cortex Dysfunction in Rats Infected
with Borna Disease Virus.
W. Ian Lipkin, University of California, Irvine.
8:15: Detection, Isolation and Molecular
Characterization of Human BDV. Daniel
Gonzalez-Dunia, The Scripps
Research Institute.
8:30: Schizophrenia and Borna Disease – Clinical
Relationships in a Monozygotic Twin Study Cohort.
Royce W. Waltrip III,
Maryland Psychiatric Research Center.
8:45:
OPEN MICROPHONE PRESENTATIONS AND DISCUSSIONS
SATURDAY,
NOVEMBER 4, 1995
SESSION
I: INFECTIOUS AGENTS AND PSYCHIATRIC DISEASE — POTENTIAL
MECHANISMS
KEYNOTE
SPEAKER
9:00: Virus Infection of Neurons, Disordered CNS
Function and Resultant Neuropsychiatric Disease. Michael B. A. Oldstone,
M.D., The Scripps Research Institute.
9:45: The Immunopathogenesis of Virus-Induced
Myocarditis. Noel
R. Rose, M.D., Ph.D., The Johns Hopkins University.
10:15: Viral Models for Persistent Neurological Infection.
Diane Griffin, M.D.,
Ph.D, The Johns Hopkins University.
10:45:
BREAK
11:00:
Geographic Correlation of Schizophrenia and
Ixodes Tick-Borna Viruses. James S. Brown, M.D., U.S. Military Academy.
11:15: Simultaneous Analysis of Multiple DNA Suspects
From Twins Discordant for Schizophrenia.
Cassandra L. Smith,
Boston University.
11:30: Calcium Dysregulation in Major Mood
Disorders. Martha M. Coetzee,
Uniformed Services University of the Health Sciences.
11:45: Viral Research in Schizophrenia: Phenomenological
Considerations. William T. Carpenter, University of Maryland
School of Medicine.
12:00
LUNCH/POSTER PRESENTATIONS
Possible Suppression of Herpes Simplex Virus
Infections with Lithium Carbonate.
Jay D. Amsterdam, Greg Maislin,
University of Pennsylvania Medical Center.
Viral Etiology and Seasonality of Schizophrenic
Births in Barbados. Ram Rao Malesu, K. McKenzie, R. Murray, Institute
of Psychiatric, Genetics Sections, London.
A 7-Year Prospective Study of Long-Term Lithium
Effect on Affective and Labial Herpes Recurrences in Bipolar Patients.
Janusz K. Rybakowski and Jay D. Amsterdam, Department of Adult
Psychiatry, University of Medical Sciences, Poland and University
of Pennsylvania Medical Center.
Seroepidemiological Studies of Prenatal Viral
Infection and Adult Schizophrenia. Alan S. Brown, New York State Psychiatric
Institute.
SESSION
II: ANIMAL MODELS OF PSYCHIATRIC DISEASES
1:00: A New Foamy Retrovirus From An Orang-Utan With
Encephalopathy. Myra O. McClure, St. Mary’s Hospital Medical
School, U.K.
1:15: Virus-Induced Pathology in the Developing
Hippocampus May Involve Disruption of Inhibitory Circuits.
Brad D. Pearce, Emory
University School of Medicine.
1:30: Altered Brain FYN Kinase in a Murine
AIDS. Yoshitatsu Sei, NIDDK,
NIH.
1:45: Surrogate Markers’ for Encephalopathy in the
SIV-Infected Rhesus Monkey.
Lee E. Eiden, National Institute of Mental
Health.
2:00: Attempts to Passage a Transmissible Growth Agent
From CSF of Schizophrenic Patients to Neonatal Mice.
Janice R. Stevens,
Oregon Health Sciences University.
2:15: Localization of Viral Message in Brains of Cats
Exposed Postnatally to Bovine Viral Diarrhea Virus.
Susan E. Bachus,
National Institute of Mental Health.
2:30: Decreased Levels of A Lipid in the Brain Frontal
Lobe in Patients With Schizophrenia. Subrato Chatterjee, The Johns Hopkins
University School of Medicine.
2:45:
OPEN MICROPHONE PRESENTATIONS AND DISCUSSION
3:15: Meeting Summary and Conclusions. E. Fuller Torrey, M.D.,
National Institute of Mental Health.
Last revised on 05 June 2000.
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