Stanley Division of Developmental Neurovirology | Publications

Stanley Division of Developmental NeurovirologyStanley Division of Developmental NeurovirologyStanleylab.orgStanleylab.orgStanleylab.org

Stanleylab.org

People/StaffPublicationsMeetings & EventsDepartments/ProgramsFellowship ApplicationLaboratory Procedures


POLYMORPHISMS IN THE HOMEOBOX GENE OTX2 MAY BE A RISK FACTOR FOR BIPOLAR DISORDER

Am J Med Genet B Neuropsychiatr Genet. 2007 May 31; [Epub ahead of print]

Sabunciyan S, Yolken R, Ragan CM, Potash JB, Nimgaonkar VL, Dickerson F, Llenos IC, Weis S

Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, Maryland

ABSTRACT

We investigated the possible involvement of OTX2, a homeobox gene crucial for forebrain development, in the pathogenesis of schizophrenia and bipolar disorder. The disruption of this gene results in cortical malformations and causes serotonergic and dopaminergic cells in the midbrain to be expressed in aberrant locations. Resequencing of DNA from OTX2 exons and surrounding introns from 60 individuals (15 schizophrenia, 15 bipolar disorder, 15 depression, and 15 control) revealed two intronic polymorphisms, rs2277499 (C/T) and rs28757218 (G/T), but no other variations. The minor allele of rs2277499 (T) did not associate with clinical diagnosis. However, using a Taqman genotyping assay, we found the rs28757218 minor allele (T) in 30 our of 720 (4.2%) individuals with bipolar disorder but only I 6 out of 526 (1.1%) control individuals (odds ratio 3.5, 95% confidence interval 1.4-10.4, P = 0.003). On the other hand, the rs287218 minor allele was only found in 6 our of 458 (1.3%) individuals with schizophrenia. All individuals with the rs28757218 polymorphism were heterozygous for the allele. Based on this positive case-control association finding, we conclude that variations in OTX2 might confer risk for the development of bipolar disorder.

 

Stanley Division of Developmental NeurovirologyJohn Hopkins Medicine

Home | People/Staff | Publications | Meetings & Events | Departments/Programs | Fellowship Application
Laboratory Procedures | About Us | Contact Us | Sitemap | Internal Use

©2005-2010 Stanley Division of Developmental Neurovirology

developed by Americaneagle.comAmericaneagle.com