Uncategorized

VIRUSES AND SCHIZOPHRENIA; A FOCUS ON HERPES SIMPLEX VIRUS

Herpes 11:2(Suppl):83A-88A, 2004 Robert Yolken ABSTRACT: Various factors have been implicated in the pathogenesis of schizophrenia. Evidence for an infectious cause includes the 508% increased risk among those born in the winter-spring months, when infectious diseases are more prevalent and at times when other infections (measles, varicella, poliomyelitis) show increased activity. Herpes simplex virus (HSV) …

VIRUSES AND SCHIZOPHRENIA; A FOCUS ON HERPES SIMPLEX VIRUS Read More »

TOXOPLASMA ANTIBODY TITERS IN TREATMENT NAIVE FIRST EPISODES OF SCHIZOPHRENIA

To explore the contribution of infectious exposure to schizophrenia, we determined the levels of several antibodies to infectious agents in blood samples collected in a randomized double-blind 52 week clinical trial in China.  The sample included 160 first-episode schizophrenia patients and 60 normal controls balanced in distribution of age (28 ±7), gender (53% male vs. …

TOXOPLASMA ANTIBODY TITERS IN TREATMENT NAIVE FIRST EPISODES OF SCHIZOPHRENIA Read More »

CENTRAL NERVOUS SYSTEM AND SYSTEMIC QUINOLINIC ACID IN SCHIZOPHRENIA

CENTRAL NERVOUS SYSTEM AND SYSTEMIC QUINOLINIC ACID IN SCHIZOPHRENIA LD Bobo*, RH Yolken, EF Torrey, JD Paltan-Ortiz, MM Herman, NC Briggs, H Velasco, M Zito, MP Heyes Stanley Research Foundation, NAMI, Washington DC Immunologic marker elevations in schizophrenia have been reported. Quinolinic acid (QUIN), a potential neurotoxic product of immune-activated macrophages and microglia, has been …

CENTRAL NERVOUS SYSTEM AND SYSTEMIC QUINOLINIC ACID IN SCHIZOPHRENIA Read More »

Publication

VIRUSES AND SCHIZOPHRENIA; A FOCUS ON HERPES SIMPLEX VIRUS Herpes 11:2(Suppl):83A-88A, 2004 Robert Yolken ABSTRACT: Various factors have been implicated in the pathogenesis of schizophrenia. Evidence for an infectious cause includes the 508% increased risk among those born in the winter-spring months, when infectious diseases are more prevalent and at times when other infections (measles, …

Publication Read More »

Welcome

The overall goal of The Stanley Neurovirology Laboratory of the Johns Hopkins University School of Medicine is to develop a training and research program devoted to the elucidation of the role of infection and immunity in the etiology of schizophrenia and bipolar disorders. Consumers: See Department/Programs

ABSTRACT SUBMISSION

THE 7TH SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISORDER – FOCUS ON GENOMICS, PROTEOMICS AND CLINICAL TRIALS WAS A HUGH SUCCESS.   ABSTRACTS AND SLIDES FROM THE MEETING ARE NOW ON THIS SITE.  CLICK HERE TO VIEW  WE THANK EVERYONE FOR THEIR PARTICIPATION WE WILL NOT HAVE A GENERAL MEETING FOR 2002.  WE …

ABSTRACT SUBMISSION Read More »

Archives of General Psychiatry

Archives of General Psychiatry, 2003; in press Antibodies to Herpes Simplex Virus Type 1 Is Associated With Cognitive Deficits in Individuals With Schizophrenia Faith B. Dickerson, John J. Boronow, Cassie Stallings, Andrea E. Origoni, Inna Ruslanova, Robert H. Yolken BACKGROUND:  Cognitive deficits are a characteristic feature of schizophrenia and contribute to the profound disabilities associated …

Archives of General Psychiatry Read More »

Stanley Lab: Pictures

      This page uses frames, but your browser doesn’t support them. Click here to continue to the no-frames version. Picture Gallery 1999 Stanley Division Staff 1999 Stanley Laboratory Staff 1999 Viscidi Lab Staff Last revised on 05 June 2000.

METABOLITES OF THE ANTIPSYCHOTIC AGENT CLOZAPINE INHIBIT THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

Abstract Schizophrenia is a serious and often debilitating neuropsychiatric disease of worldwide importance. Current therapy relies on the use of typical antipsychotic medications, which specifically inhibit binding of ligand at the D2 dopamine receptor, and atypical medications which display little activity for this receptor interaction. While atypical antipsychotic agents have been shown to variably inhibit …

METABOLITES OF THE ANTIPSYCHOTIC AGENT CLOZAPINE INHIBIT THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 Read More »

METABOLITES OF THE ANTIPSYCHOTIC AGENT CLOZAPINE INHIBIT THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

METABOLITES OF THE ANTIPSYCHOTIC AGENT CLOZAPINE INHIBIT THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 Lorraine V. Jones-Brando, James L. Buthod, Louis E. Holland, Robert H. Yolken, E. Fuller Torrey Abstract Schizophrenia is a serious and often debilitating neuropsychiatric disease of worldwide importance. Current therapy relies on the use of typical antipsychotic medications, which specifically …

METABOLITES OF THE ANTIPSYCHOTIC AGENT CLOZAPINE INHIBIT THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 Read More »