Stanley Division of Developmental Neurovirology | Publications – amminger gp

Stanley Division of Developmental NeurovirologyStanley Division of Developmental NeurovirologyStanleylab.orgStanleylab.orgStanleylab.org

Stanleylab.org

People/StaffPublicationsMeetings & EventsDepartments/ProgramsFellowship ApplicationLaboratory Procedures


ANTIBODIES TO INFECTIOUS AGENTS IN INDIVIDUALS AT ULTRA HIGH RISK FOR PSYCHOSIS

Biol Pyschiatry. 2007 May 15;61(10):1215-7. Epub 2007 Jan 3.

Amminger GP, McGorry PD, Berger GE, Wade D, Yung AR, Phillips LJ, Harrigan SM, Francey SM, Yolken RH

ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia. [email protected]

ABSTRACT

BACKGROUND: While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis. METHODS: Participants were 105 help seeking ultra-high risk individuals. Psychiatric measures included the Brief Psychiatric Rating Scale and the Scale for the Assessment of Negative Symptoms. Serum IgG antibodies against human herpesviruses and Toxoplasma gondii were determined using immunoassay methods. Multiple linear regression with adjustment for age and sex was applied to test associations between serum antibodies and psychiatric measures. RESULTS: Higher levels of serum IgG antibodies against Toxoplasma gondii in Toxoplasma-positive individuals were significantly associated with more severe positive psychotic symptoms. No significant association was observed between antibody levels and psychiatric measures in individuals positive for human herpesviruses. CONCLUSIONS: In some individuals infection with Toxoplasma gondii may be an environmental factor contributing to the manifestation of positive psychotic symptoms.

 

Stanley Division of Developmental NeurovirologyJohn Hopkins Medicine

Home | People/Staff | Publications | Meetings & Events | Departments/Programs | Fellowship Application
Laboratory Procedures | About Us | Contact Us | Sitemap | Internal Use

©2005-2010 Stanley Division of Developmental Neurovirology

developed by Americaneagle.comAmericaneagle.com