Symposium on the Neurovirology and Neuroimmunology of
Schizophrenia and Bipolar Disorder
November 14, 1996
8:00-9:00: Check in
and Continental Breakfast
NEUROVIROLOGY LABORATORY OF THE JOHNS
9:00: Robert H. Yolken: Overview of the Stanley Laboratory
Program-Do We Really Think that Infections Can Cause Human
9:20: Frances Yee: Viral and Virus-Related RNA Transcripts
Are Differentially Expressed in the Brains of Individuals with
9:40: Linda Bobo: Correlation of Schizophrenia and
Bipolar Disorder with Cytokine and Cytokine Receptors in
Ventricular Fluids and Postmortem Brain Tissue.
10:00: Nancy Johnston: Measurement of RNA from 89 Postmortem
Human Brains; A Multivariate Statistical Analysis of Pre- and
Post Mortem Effects on the Yields of GAPdH As Measured by RT-PCR.
10:20: Indra De: Detection of Viral Particles in Glial
Cells Inoculated with Brain Tissue from Individuals with
Schizophrenia and Bipolar Disease.
10:40: COFFEE BREAK
11:00: Yeping Sun: Serial Analysis of Gene Expression of
Human Brain Tissue.
11:20: Raphael Viscidi: Genomic Differential Display Enriched
for Retroviral LTR Sequences.
SESSION II: OTHER
NEUROLOGICAL AND INFECTIOUS DISEASES-WHAT CAN BE APPLIED TO THE
UNDERSTANDING OF SCHIZOPHRENIA AND BIPOLAR DISEASE
1:30: Sangram S. Sisodia, Johns Hopkins
University, Department of Pathology and Neurosciences, Baltimore,
Biology of Alzheimer’s Disease.
2:00: Christopher Ross, Johns Hopkins
University, Department of Neurobiology, Baltimore, MD: Genetics of Huntington’s Disease:
Lessons for Psychiatry.
2:30: Krister S. Kristensson, Karolinska
Institutet, Department of Neurosciences, Stockholm, Sweden: Trypanosoma Brucei Dysregulates the
Mammalian Circadian Clock.
3:00: Lorraine Jones-Brando, Johns Hopkins
University, The Stanley Neurovirology Laboratory, Baltimore, MD: Cytomegalovirus and Post-Transplant
3:35: Shizuku Sei, National Institutes of
Health, NCI, Bethesda, MD:
Virological Aspects of Neuropathogenesis of HIV-1 Disease.
3:55: Larisa Cervenakova, National Institutes
of Health, Laboratory of the Central Nervous System Studies,
Bethesda, MD: DNA
Polymorphism and Susceptibility to Environmentally Acquired
4:15: Steven Jacobson, National Institutes of
Health, Neuroimmunology Branch, Bethesda, MD: Association of HHV-6 and Multiple
4:35: Dharam V. Ablashi, Georgetown University
Medical School, Washington DC: Higher Frequency of Human Herpesvirus-6
(HHV-6) Antibody in Cerebral Spinal Fluids and Sera from Multiple
Viewing (Wine and Cheese provided)
SUNY, Department of Microbiology, Buffalo, NY: Susceptibility of Human Macrophages to
Paromita Deb, The
University of Western Ontario, Department of Zoology, London,
Investigation of Insertional Mutagenesis of “Retroid”
Elements in the Human Genome with Reference to Schizophrenia.
John H. Gilmore,
University of North Carolina School of Medicine, Department of
Psychiatry, Chapel Hill, NC:
Neonatal Infection Increases Neurotrophic Factor mRNA.
Hickling, Psychotherapy Associates, Connoley House, Kingston,
Incidence and Prevalence of Bipolar Affective Disorder in
Johns Hopkins University, Stanley Neurovirology Laboratory,
Comparison of cDNA Libraries From the Brains of Normal and
Schizophrenic Individuals Show Than an Unusually High Number of
Novel Sequences are Present in the Brain of the Schizophrenic
Timothy A. Klempan,
The University of Western Ontario, Department of Zoology, London,
Application and Adaptation of Representational Difference
Analysis in the Evaluation of Retroviral Hypothesis for
Mark H. Rapaport,
University of California San Diego, Department of Psychiatry, La
Jolla, CA: A Pilot
Study of Cytokine and Soluble Interleukin-2 Receptor Levels in
Symptomatic Bipolar Patients.
Venkateshan, LCNSS, NINDS, NIH, Bethesda, MD: Effect of HTLV-1 Virus, IFN-y and Quin
Precursors on Quin Response in Cultured Human Monocytes and
Discussions and Answer
INFECTIONS AND HUMAN PSYCHIATRIC DISEASES
Norrby, Karolinska Institute, Microbiology and Tumor Biology
Center, Stockholm, Sweden:
Measles Virus Invasion Through Limbic Structures in Mice with
Disrupted Gene for the Transporter Associated with Antigen
10:00: Alan S. Brown, NYS Psychiatric
Institute/Columbia University, New York, NY: Psychosis After Prenatal Exposure to
10:20: Mady Hornig-Rohan, University of
Pennsylvania, University Science Center, Depression Research
Unit, Philadelphia, PA:
Rates of Flu-Like Illness in Patients with Affective Disorders.
John Martin, Center for Complex Infectious Diseases, Rosemead, CA: Instability of SCMV-Derived Stealth
11:20: Susan Swedo, National Institutes of
Mental Health, Bethesda, MD:
PANDAS: Is There a New “Species” of Pediatric
11:40: Brad D. Pearce, Emory University School
of Medicine, Department of Psychiatry, Atlanta, GA: The Immune Response in the Disruption
of Hippocampal GABA Circuits Following Neonatal Infection with
Lymphocytic Choriomeningitis Virus (LCMV).
IMMUNOLOGY AND PATHOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISEASE
1:30: Mark H. Rapaport, University of
California San Diego, Department of Psychiatry, LaJolla, CA: Evidence of Differences in Immune
Function in Older & Younger Schizophrenic Patients: Is This
Age or A Function of Severity of Illness.
1:50: Pinkhas Sirota, Abarbanel Mental Health
Center, Bat-Yam Felsenstein Medical Institute, Bat-Yam, Israel: Antibodies to Neural Tissue Proteins in
2:10: van Kammen, Daniel P., Department of
Veterans Affairs, Medical Center, Pittsburgh, PA: The Role of Immune Measures in
Psychosis and Stress Sensitivity in Schizophrenia.
2:30: Barbara B. Mittleman, NIMH, Unit on
Neuroimmunology, Behavioral Pediatrics Section, Child Psychiatry
Branch, Bethesda, MD:
The Role of Cytokines in Untreated and Treated Childhood Onset
3:10: Steve Zalcman, Concordia University,
Department of Psychiatry, Montreal, Canada: Interleukin-6 Sensitizes Rats to the
Locomotor-Activating Effects of Amphetamine.
3:30: Guoqiang Xing, National Institutes of
Mental Health, Bethesda, MD:
PPARõ And Its Potential Involvement in Schizophrenia.
3:50: Cassandra L. Smith, Boston University,
Departments of Biomedical Engineering, Biology and Pharmacology,
Detection and Quantitation of Genomic Differences in
Microsatellites of Monozygotic Twins.
4:10: N.L. Anderson, Large Scale Biology
Corporation, Rockville, MD:
Characterization of Disease Processes and Pharmaceutical
Mechanisms Through Quantitative High-Throughput 2-D
4:30: Jhy-Jhu Lin, Life Technologies, Inc
(GIBCO/BRL), Gaithersburg, MD: A New PCR-Based DNA Fingerprinting
4:50: Janice R. Stevens, Oregon Health Sciences
University, Department of Psychiatry, Portland, OR: Do the Anatomy and Course of
Schizophrenia Assist In the Search for Etiology?
EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF BORNA DISEASE
7:00: Kathryn Carbone, FDA, Laboratory of
Pediatric & Respiratory Viral Diseases, Bethesda, MD: Borna Disease Virus in Psychiatric
7:30: Juan C. de la Torre, The Scripps Research
Institute, La Jolla, CA:
Borna Disease Virus in Humans.
7:50: Royce W. Waltrip II, Maryland Psychiatric
Research Center, Baltimore, MD: Borna Disease Virus Serology in a First
Episode Schizophrenia Cohort.
8:10: Masahiko Kishi, Hokkaido University
Institute of Immunological Science, Section of Bacterial
Infection, Sapporo, Japan:
Prevalence of Borna Disease Virus RNA in Peripheral Blood
Mononuclear Cells From Patients with Affective Disorders.
8:30: D. Craig Hooper, Thomas Jefferson
University, Center for Neurovirology, Department of Microbiology
and Immunology, Philadelphia, PA: Is Active Borna Disease Virus Infection
Really a Contributor to Human Psychiatric Disorders?
8:50: Joanne M. Pyper, Johns Hopkins University
School of Medicine, Division of Comparative Medicine, Baltimore,
Development Patterns in Rats Infected with Borna Disease Virus As
November 16, 1996
9:00: Stanley B. Prusiner, University of
California San Francisco, Department of Neurology, San Francisco,
CA: The Molecular
Biology and Genetics of Prion Diseases: A Journey from Heresy to
10:00: E. Fuller Torrey, Guest Researcher, NIMH
Neurosciences Center, Washington DC: Where Have We Been and Where are We
Going: Risk Factors and Future Directions.
10:15: Robert H. Yolken, Director, The Stanley
Neurovirology Laboratory of the Johns Hopkins University,
For a look at
individual abstracts, go to “Abstracts 1996” on the