PROTEINCHIP PROTEOMICS FOR PROFILING OF NEUROPSYCHIATRIC DISEASE

PROTEINCHIP PROTEOMICS FOR PROFILING

OF NEUROPSYCHIATRIC DISEASE

Eric Fung, Ciphergen Biosystems,

Fremont, CA

Diagnosis of Neuropsychiatric illnesses

relies predominantly on patient interviews and medical history rather than on

laboratory testing.  However, there is a need for biomarkers that are

diagnostic, predict course of disease, and stratify patients according to their

likely response to therapeutics.  As a first step toward identifying

proteins whose expression levels change in patients with schizophrenia, we have

performed ProteinChip® expression profiling of  cerebrospinal fluid (CSF)

from patients and age-matched controls.  Differences in patterns of protein

expression will be described and their potential role in the pathogenesis of

schizophrenia will be discussed.