IN VITRO INHIBITION OF TOXOPLASMA GONDII BY FOUR NEW DERIVATIVES OF ARTEMISININ

Antimicrob Agents Chemother 50(12):4206-4208, 2006

Jones-Brando, L, D’Angelo J, Posner GH, Yolken R

Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 2128-4988, USA, lbrando@jhmi.edu

ABSTRACT:

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available Medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.